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Sirolimus

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Rapamune®
    • Brand Names: Canada: Rapamune®

    Uses
    • It is used to keep the body from harming the organ after an organ transplant.
    • It is used to treat graft versus host effects after a bone marrow transplant.
    • It is used to treat soft tissue sarcoma.
    • Sirolimus helps the body accept an organ transplant.
    • It lowers the body's harmful response to diseases of the immune system.

    Dosing

    How to take

    • All products:
    • This drug is used with other drugs to help the body accept the new organ.
    • To gain the most benefit, do not miss doses.
    • Take with or without food. Always take with food or always take on an empty stomach.
    • Oral solution:
    • Put 1/4 cup of water or orange juice into a cup.
    • Measure this drug in the oral dose syringe. Empty drug from syringe into cup. Mix well and drink.
    • Fill container again with 1/2 cup of water or orange juice. Mix well and drink.
    • Tablet:
    • Swallow whole. Do not chew, break, or crush.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Tablet:
    • Store at room temperature.
    • Protect from light.
    • Protect from water. Do not store in a bathroom or kitchen.
    • Liquid:
    • Store liquid (solution) at room temperature or in a refrigerator. Throw away any part not used after 15 days if stored at room temperature. Throw away any part not used after 1 month if refrigerated.
    • Liquid (solution) may look hazy when refrigerated. Bring to room temperature and shake gently until haze goes away.
    • Store liquid (solution) in a syringe at room temperature for 24 hours.
    • Protect from light.

    Safety



    Warnings

    • This drug may add to your chance of getting lymphoma or other cancers.
    • Very bad infections have happened in patients who take this drug. Talk with the doctor.
    • Sirolimus may have very bad effects if used for liver or lung transplant.
    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.
    • Please read the medication guide.

    Avoid

    • If you have an allergy to sirolimus or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • If you have high cholesterol, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • If you have lung disease, talk with your doctor.
    • If you have skin cancer, talk with your doctor.
    • Have your blood pressure and heart rate checked often. Talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Be careful about getting vaccines while you are getting this drug.
    • Do not take cyclosporine capsules (Neoral®, Gengraf®) or oral solution (Neoral®) within 4 hours of this drug.
    • Avoid grapefruit and grapefruit juice.
    • Use birth control that you can trust before care begins, during care, and for 3 months after care ends.
    • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.

    Side Effects

    • High blood pressure.
    • High cholesterol level.
    • Chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
    • Anemia and low platelet count.
    • Feeling tired or weak.
    • Headache.
    • Belly pain.
    • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
    • Loose stools (diarrhea).
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Joint pain.
    • Swelling in the arms or legs.
    • Pimples (acne).
    • Harm to the lungs may rarely happen.
    • Kidney function that gets worse.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Trouble breathing.
    • Very bad headache.
    • Very loose stools (diarrhea).
    • Very bad swelling.
    • Skin wound that will not heal.
    • Not able to pass urine.
    • Any bruising or bleeding.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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