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Pyrimethamine

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Daraprim®
    • Brand Names: Canada: Daraprim®

    Uses
    • It is used to stop or treat malaria.
    • It may be used to stop or treat toxoplasmosis.
    • It is used to treat HIV infection.
    • Pyrimethamine works to harm the parasite and fight the infection.

    Dosing

    How to take

    • To gain the most benefit, do not miss doses.
    • Use as you have been told, even if you are feeling better.
    • Take with food to stop an upset stomach.
    • There is a liquid (suspension) if you cannot swallow pills. Shake well before use.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.

    Storage

    • Store tablets at room temperature.
    • Protect tablets from water. Do not store in a bathroom or kitchen.
    • Store liquid (suspension) at room temperature. Throw away any part not used after 1 week.
    • Protect from light.

    Safety



    Warnings

    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.

    Avoid

    • If you have an allergy to pyrimethamine or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have anemia caused by low folic acid stores.

    Precautions

    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • If you are taking this drug for more than 3 days, talk with your doctor.
    • If you have a drug or drinking problem, talk with your doctor.
    • Be careful if you have G6PD deficiency. Anemia may happen.
    • If you have malabsorption syndrome, talk with your doctor.
    • If you have seizures, talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Other measures are needed along with this drug including using screens, bed netting, insect repellent (10% to 35% DEET), and permethrin spray on clothing and nets. Avoid spraying most insect repellents on children. Lower evening and night-time outdoor activity.
    • Folic acid or leucovorin may be needed to avoid side effects. Talk with the doctor.
    • If you are pregnant or planning on getting pregnant, talk with your doctor. You may need even higher doses of folic acid.
    • If you are a pregnant woman and traveling to a malaria infested place, talk to your doctor about the risks first.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • Headache.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Belly pain.
    • Anemia and low platelet count may rarely happen.

    Monitoring

    • Change in the health problem being treated. Is it better, worse, or about the same?

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Fever that happens while in or after coming back from the malaria area.
    • Very bad dizziness or passing out.
    • Very upset stomach or throwing up.
    • Feeling very tired or weak.
    • Very loose stools (diarrhea).
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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