• U.S. Brand Names: Creon®;PancreazeT;PancrelipaseT;ZenpepT
• Canadian Brand Names: Cotazym®;Creon®;Pancrease® MT;Ultrase®;Ultrase® MT;Viokase®
• Pharmacologic Category: Enzyme

• It is used to help break down food when the pancreas is not working the right way.
• Pancrelipase acts as an enzyme replacement.
• It aids in the break down of proteins, starches, and fats.

How to take

• Take this drug with food.
• Swallow whole. Do not chew, break, or crush.
• You may sprinkle contents of capsule on applesauce. Do not chew. Swallow right away and follow with water or juice.
• Do not take dairy products, iron, or folic acid with this drug.
• Drink plenty of noncaffeine-containing liquid unless told to drink less liquid by doctor.

Missed Dose

• Take a missed dose as soon as you think about it.
• If it is close to time for the next dose, skip the missed dose and return to your normal time.
• Do not take two doses or extra doses.

Storage

• Store at room temperature.
• Protect from water. Do not store in a bathroom or kitchen.

Warnings

• Please read the medication guide.

Avoid

• If you have an allergy to pancrelipase, pork, or any other part of this drug.
• Tell doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs involved.

Precautions

• There is more than 1 brand of this drug. One brand cannot safely be used for the other. Any change must be told by doctor.
• If you have kidney disease, talk with doctor.
• Watch for gout attacks.
• Check all drugs you are taking with your doctor. This drug may not mix well with certain other drugs.
• Tell doctor if you are pregnant or plan on getting pregnant.
• Tell doctor if you are breast-feeding.

Side Effects

• Dizziness.
• Belly pain.
• Headache.
• Gas.
• Upset stomach or throwing up. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Loose stools.

Monitoring

• Change in health problem being treated. Is it better, worse, or about the same?
• Follow up with doctor.

Contact a healthcare provider

• If you suspect an overdose, call your local poison control center or ER right away.
• Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
• Trouble breathing.
• Very upset stomach or throwing up.
• Very bad loose stools.
• Very bad constipation.
• Very bad belly pain.
• Very bad joint pain.
• Any rash.
• Health problem is not better or you are feeling worse.

General Statements

• If you have a very bad allergy, wear allergy ID at all times.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep all drugs out of the reach of children and pets.
• Most drugs can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• In Canada return any unused drugs back to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th for more facts about the right way to get rid of unused drugs.
• Keep a list of all your drugs (prescription, natural products, supplements, vitamins, OTC) with you. Give this list to your doctor.
• Call your doctor for health help about side effects. You may also call the FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with doctor before starting any new drug, including OTC, natural products, or vitamins.

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