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Oxycodone and Ibuprofen


Related terms
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    Related terms

      • It is used to ease pain.
      • Oxycodone lowers the feeling of pain and how one reacts to pain.
      • Ibuprofen blocks chemicals that cause pain and swelling.


      How to take

      • Do not take this drug with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
      • Take with or without food. Take with food if it causes an upset stomach.
      • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
      • Keep a pain diary.

      Missed Dose

      • Do not take 2 doses at the same time or extra doses.
      • Many times this drug is taken on an as needed basis.


      • Store at room temperature.
      • Protect from water. Do not store in a bathroom or kitchen.



      • This drug may raise the chance of heart attack, stroke, and high blood pressure. This has been seen with long-term use or at urgent times (right after heart surgery). Use care if you have risks for heart disease (high blood pressure, high cholesterol, overweight, high blood sugar (diabetes), cigarette smoking, man older than 40 years of age, other family members with early heart disease, woman after change of life).
      • Do not use this drug right before or after heart bypass surgery.
      • This drug may raise the chance of ulcers or bleeding from the stomach or bowel. Talk with the doctor.
      • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.
      • Please read the medication guide.


      • If you have an allergy to oxycodone, ibuprofen, or any other part of this drug.
      • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
      • If you have any of these health problems: Asthma, bowel block, or lung disease.
      • If you are more than 30 weeks pregnant.
      • If you are breast-feeding.


      • This drug may be habit-forming with long-term use.
      • If you have a history of a drug or drinking problem, talk with your doctor.
      • If you have kidney disease, talk with your doctor.
      • If you have liver disease, talk with your doctor.
      • If you have seizures, talk with your doctor.
      • If you have thyroid disease, talk with your doctor.
      • If you have had an ulcer or bleeding from your stomach or bowel, talk with your doctor.
      • If you have a weak heart, talk with your doctor.
      • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
      • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
      • Talk with your doctor before using products that have aspirin, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain drugs, or vitamin E.
      • Do not take colestipol or cholestyramine within 2 hours of this drug.
      • Avoid drugs and natural products that slow your actions. These include sedatives, tranquilizers, drugs for mood, antihistamines, and other pain drugs.
      • Avoid beer, wine, or mixed drinks.
      • Tell dentists, surgeons, and other doctors that you use this drug.
      • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
      • Tell your doctor if you are pregnant or plan on getting pregnant.

      Side Effects

      • Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
      • Headache.
      • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
      • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.

      Contact a healthcare provider

      • If you think there was an overdose, call your local poison control center or ER right away.
      • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
      • Very bad dizziness or passing out.
      • Chest pain or pressure.
      • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
      • Trouble breathing.
      • Change in thinking clearly and with logic.
      • Poor pain control.
      • Very upset stomach or throwing up.
      • Very bad belly pain.
      • Very bad swelling or pain of hands or feet.
      • A big weight gain.
      • Black, tarry, or bloody stools.
      • Blood in the urine.
      • Very hard stools (constipation).
      • Any bruising or bleeding.
      • Feeling very tired or weak.
      • Any rash.
      • Side effect or health problem is not better or you are feeling worse.

      General Statements

      • If you have a very bad allergy, wear an allergy ID at all times.
      • Do not share your drugs with others and do not take anyone else's drugs.
      • Keep all drugs out of the reach of children and pets.
      • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
      • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
      • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
      • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
      • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

      Author information
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      Copyright © 2011 Natural Standard (

      The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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