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Related terms
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    Related terms
    • Brand Names: U.S.: MinitranT;Nitro-Bid®;Nitro-Dur®;Nitro-Time®;Nitrolingual®;NitroMist®;Nitrostat®;Rectiv®
    • Brand Names: Canada: MinitranT;Mylan-Nitro Sublingual Spray;Nitro-Dur®;Nitroglycerin Injection, USP;Nitrol®;Nitrostat®;Rho®-Nitro Pump Spray;Transderm-Nitro®;Trinipatch®

    • It is used to stop or treat chest pain or pressure.
    • It is used to help a weak heart.
    • It is used to treat anal pain.
    • Nitroglycerin calms blood vessels.
    • It calms rectal and anal muscles.


    How to take

    • Sublingual (under the tongue):
    • Sit down before use.
    • Sublingual tablet: Place under your tongue and let melt.
    • Wait 5 minutes. If chest pain or pressure is still present, call the ER (emergency department) or get a ride to the hospital. Do not drive yourself.
    • Spray:
    • Spray on or under tongue.
    • Avoid swallowing after use.
    • Avoid rinsing mouth for 5 to 10 minutes after use.
    • Wait 5 minutes. If chest pain or pressure is still present, call the ER (emergency department) or get a ride to the hospital. Do not drive yourself.
    • Nitrolingual®:
    • Prime pump by spraying it 5 times.
    • If not used in 6 weeks prime pump by spraying it 1 time.
    • NitroMistT:
    • Prime pump by spraying it 10 times.
    • If not used in 6 weeks prime pump by spraying it 2 times.
    • Oral:
    • Take oral products on an empty stomach. Take 1 hour before meals or 2 hours after meals.
    • Long-acting products: Swallow whole. Do not chew, break, or crush.
    • Take with a full glass of water.
    • Skin: Ointment (topical):
    • Wash your hands before and after use.
    • Use the applicator or dose-measuring paper to spread in a thin layer over a 2x3 inch part. Put on your chest or back.
    • Rectal:
    • Cover your finger with plastic-wrap, a surgical glove, or a finger cot.
    • Use the dosing guide on the box to put the ointment on your covered finger.
    • Place the finger with the ointment on it into the anal canal up to the first finger joint.
    • Smear the ointment inside the anus.
    • You may also put the ointment on the outside of your anus.
    • Wash your hands after use.
    • Patch:
    • Follow how to use as you have been told by your doctor or read the package insert.
    • Put patch on at the same time of day.
    • Put patch on a site without hair.
    • Shot:
    • It is given as a shot into a vein over a period of time.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Many times this drug is taken on an as needed basis.


    • Oral:
    • Store at room temperature.
    • Protect from light.
    • Protect capsules and tablets from water. Do not store in a bathroom or kitchen.
    • Store sublingual tablets in the original container at room temperature. Keep the cap tightly closed. Throw away any part not used when the date on the bottle has been reached.
    • Shot:
    • The shot will be given to you in a hospital or doctor's office. You will not store it at home.



    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.


    • If you have an allergy to nitroglycerin or any other part of this drug.
    • If you have an allergy to adhesive.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Anemia, bleeding in the brain, or head injury.


    • Wear disease medical alert ID (identification).
    • The patch may have metal. Take off the patch before an MRI.
    • Have your blood pressure and heart rate checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Avoid beer, wine, or mixed drinks.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • Flushing. Wearing layers of clothes or summer clothes and staying in cool places may help.
    • Headache. Most of the time it gets better after taking this drug for a week.
    • Skin irritation.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Chest pain or pressure lasting more than 15 minutes. Get emergency medical care right away.
    • Raised rate, time it lasts, or harshness of chest pain.
    • Very bad dizziness or passing out.
    • Trouble breathing.
    • Very bad headache.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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