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Estradiol and Levonorgestrel

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: ClimaraPro®

    Uses
    • It is used to put off soft, brittle bones (osteoporosis) in women after change of life.
    • It is used to stop or lower the signs of stopping periods (menopause).
    • When the body no longer makes estrogen, this drug puts back the estrogen.
    • Levonorgestrel lowers endometrial cell changes and the chance of endometrial cancer.

    Dosing

    How to take

    • Put patch on clean, dry, healthy skin on the lower belly. Move the site with each new patch.
    • Do not place on breast. Place below waistline.
    • Follow the diet and workout plan that your doctor told you about.

    Missed Dose

    • Use a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.

    Storage

    • Store at room temperature.

    Safety



    Warnings

    • Estrogens, when used in women after stopping periods (menopause), may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to your doctor.
    • Do not take estrogens to stop heart disease or dementia. Using estrogens may raise your chances of having a heart attack, a stroke, breast cancer, or a blood clot.
    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.

    Avoid

    • If you have an allergy to estradiol, levonorgestrel, or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Blood clots, breast cancer, stroke, tumor where estrogen makes it grow, or vaginal bleeding.
    • If you have surgery and need bed rest.
    • If you turned yellow during pregnancy or with estrogen-based or hormone contraceptive use.

    Precautions

    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • There may be a higher chance of breast cancer.
    • If you have any blood flow problems, talk with your doctor.
    • If you have gallbladder disease, talk with your doctor.
    • If you have heart disease, talk with your doctor.
    • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
    • If you have kidney disease, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • If you have migraine headaches, talk with your doctor.
    • Tell dentists, surgeons, and other doctors that you use this drug.
    • Have your blood pressure and heart rate checked often. Talk with your doctor.
    • Have your blood work checked. Talk with your doctor.
    • If you are taking a blood thinner, have your blood work checked. Talk with your doctor.
    • Have a bone density test. Talk with your doctor.
    • Do monthly breast self-exams and have a gynecologic exam every year.
    • Have an eye exam every year.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Avoid grapefruit and grapefruit juice.
    • Do not take St John's wort, dong quai, black cohosh, saw palmetto, red clover, or ginseng with this drug.
    • If you are taking this drug and have high blood pressure, talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids.
    • Avoid cigarette smoking. People older than 35 years of age and/or smoking more than 15 cigarettes per day have more chance for heart disease.
    • Limit your drinking of wine, beer, or mixed drinks.
    • To protect from diseases caused by having sex, use a latex condom.
    • Protect patch from the sun.

    Side Effects

    • Low mood (depression).
    • Weight gain.
    • Headache.
    • Belly pain.
    • Back pain.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Swelling.
    • Enlarged breasts.
    • Skin irritation.
    • For women, vaginal yeast infection. Report itching or discharge.
    • Gallbladder disease, blood clots, heart attacks, and other blood vessel problems may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
    • Chest pain or pressure.
    • Trouble breathing.
    • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
    • Swelling, warmth, or pain in the leg or arm.
    • Very bad headache.
    • Very upset stomach or throwing up.
    • Change in how contact lenses feel in the eyes.
    • Sudden change in eyesight, eye pain, or irritation.
    • A lump in the breast or breast soreness.
    • Very bad skin irritation.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.
    • Read the package insert for more details.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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