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Dihydroergotamine

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: D.H.E. 45®;Migranal®
    • Brand Names: Canada: Migranal®

    Uses
    • It is used to treat migraine headaches.
    • Ergotamine squeezes blood vessels in the brain to stop irritation and swelling.

    Dosing

    How to take

    • Shot:
    • It is given as a shot into a muscle, vein, or into the fatty part of the skin.
    • Your doctor may teach you how to give the shot.
    • Wash your hands before and after use.
    • Throw away needles in a needle/sharp disposal box and take the box back to your doctor when it is full.
    • If you get more attacks the same day, do not use unless at least 6 hours have passed since your last shot.
    • Nose spray:
    • For breathing by the nose. Prime pump by squeezing it 4 times. Breathe in 1 spray in each nostril. Wait 15 minutes. Breathe in 1 more spray in each nostril.

    Missed Dose

    • This drug is taken on an as needed basis.

    Storage

    • Store at room temperature. Do not freeze.
    • Once the nose spray is ready, throw away any part of the opened ampul not used after 8 hours.
    • Shot:
    • Protect from light.

    Safety



    Warnings

    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.

    Avoid

    • If you have an allergy to dihydroergotamine or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Heart disease, kidney disease, liver disease, poor blood flow, poor bowel blood flow, recent heart attack, bad infection, or very high blood pressure.
    • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking both at the same time could cause risky high blood pressure.
    • If you have taken almotriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, or zolmitriptan in the last 24 hours.
    • If you have taken ergotamine or methysergide in the last 24 hours.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Avoid grapefruit and grapefruit juice.
    • Avoid cigarette smoking.
    • Use care if you have risks for heart disease (high blood pressure, high cholesterol, overweight, high blood sugar (diabetes), cigarette smoking, man older than 40 years of age, other family members with early heart disease, woman after change of life). Talk with your doctor.
    • Use birth control that you can trust to stop pregnancy while taking this drug.

    Side Effects

    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Nose irritation.
    • Bad taste in your mouth. This most often goes back to normal.

    Monitoring

    • Change in the health problem being treated. Is it better, worse, or about the same?
    • Follow up with the doctor.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
    • Chest pain or pressure or a fast heartbeat.
    • Numbness or tingling in your hands or feet.
    • Very bad dizziness or passing out.
    • Trouble breathing.
    • Very bad muscle pain or weakness.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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