Table of Contents > Drug > Cyclophosphamide Print

Cyclophosphamide

Image

Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: Canada: Procytox®

    Uses
    • It is used to treat cancer.
    • It is used before a bone marrow transplant.
    • It is used to treat rheumatoid arthritis.
    • It is used to treat Wegener's granulomatosis.
    • It is used to treat antibody-induced pure red cell aplasia.
    • It is used to treat autoimmune hemolytic anemia.
    • It is used to treat idiopathic thrombocytic purpura (ITP).
    • It is used to treat lupus.
    • It is used to treat macroglobulinemia.
    • It is used to treat MS (multiple sclerosis).
    • It is used to treat myasthenia gravis.
    • Cyclophosphamide harms cancer cells causing their death.
    • It lowers the body's harmful response to diseases of the immune system.

    Dosing

    How to take

    • Oral:
    • Take with food.
    • Swallow tablet whole. Do not chew, break, or crush.
    • A liquid may be made if you cannot swallow the tablets.
    • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
    • Shot:
    • It is given as an infusion into a vein over a period of time.

    Missed Dose

    • Oral:
    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Oral:
    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.

    Safety



    Warnings

    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.

    Avoid

    • If you have an allergy to cyclophosphamide or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • If you have kidney disease, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • If you have a weak heart, talk with your doctor.
    • Have your blood work checked. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Talk with your doctor before getting any vaccines. Use with this drug may either raise the chance of an infection or make the vaccine not work as well.
    • Talk with your doctor before using products that have aspirin, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain drugs, or vitamin E.
    • Pass urine often. You need to empty your bladder often. Drinking lots of liquids will help.
    • Use birth control that you can trust to stop pregnancy while taking this drug.
    • If you are a man and have sex, protect your partner from pregnancy. Use birth control that you can trust.

    Side Effects

    • Chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
    • Headache.
    • Anemia, low white blood cell count, and low platelet count.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Hair loss. Hair most often grows back when this drug is stopped.
    • May not be able to get pregnant.
    • Bladder irritation.
    • Other kinds of cancer may rarely happen later in life.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Shortness of breath.
    • Very bad belly pain.
    • Very upset stomach or throwing up.
    • Very bad back pain.
    • Not able to eat.
    • Any bruising or bleeding.
    • Dark urine or yellow skin or eyes.
    • Blood in the urine.
    • Not able to pass urine.
    • Feeling very tired or weak.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

    Search Site