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Bortezomib

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Velcade®
    • Brand Names: Canada: Velcade®

    Uses
    • It is used to treat multiple myeloma.
    • It is used to treat lymphoma.
    • It is used to treat amyloidosis.
    • Bortezomib harms cancer cells causing their death.

    Dosing

    How to take

    • It is given as a shot into a vein.
    • It is given as a shot into the fatty part of the skin.

    Safety



    Warnings

    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.

    Avoid

    • If you have an allergy to bortezomib, boron, mannitol, or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • If you have high blood sugar (diabetes), talk with your doctor.
    • If you have heart disease, talk with your doctor.
    • If you have high blood pressure, talk with your doctor.
    • If you have liver disease, talk with your doctor.
    • Have your blood work checked. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Do not take St John's wort with this drug. This drug may not work as well.
    • Avoid grapefruit and grapefruit juice.
    • Avoid multivitamins, natural products, and diet aids that have extra vitamin C.
    • Avoid green tea and green tea extracts.
    • Use birth control that you can trust to stop pregnancy while taking this drug.

    Side Effects

    • Anemia, low white blood cell count, and low platelet count.
    • Blurred eyesight. Use care when driving or doing other tasks that call for clear eyesight.
    • Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
    • Loose stools (diarrhea).
    • Low blood pressure.
    • Anemia.
    • Viral infection.
    • Fever.
    • Feeling tired or weak.
    • Numbness and tingling.
    • Muscle pain.
    • Headache.

    Contact a healthcare provider

    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Very bad dizziness or passing out.
    • Very upset stomach or throwing up.
    • Very bad swelling.
    • Very loose stools (diarrhea).
    • Numbness or tingling in your hands or feet.
    • Trouble breathing.
    • Sudden change in eyesight.
    • Not able to eat.
    • Cough that does not go away.
    • Feeling very tired or weak.
    • Change in thinking clearly and with logic.
    • Any bruising or bleeding.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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