Table of Contents > Drug > OnabotulinumtoxinA Print



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    Related terms
    • Brand Names: U.S.: Botox®;Botox® Cosmetic
    • Brand Names: Canada: Botox®;Botox® Cosmetic

    • It is used to lower the number of lines and wrinkles of the face and neck.
    • It is used to lower underarm sweating.
    • It is used to stop migraine headaches.
    • It is used to treat anal fissures.
    • It is used to treat muscle problems around the eye.
    • It is used to treat muscle problems that lead to spasms.
    • It is used to treat spasms of the head. It may take 2 weeks to get better.
    • It is used to treat an overactive bladder in patients with spinal cord injury or MS (multiple sclerosis).
    • OnabotulinumtoxinA paralyzes the muscle getting the shot.
    • It lowers sweating.
    • It lowers the need to pass urine often.


    How to take

    • It is given as a shot into the muscle(s) causing the spasms.
    • It may be given as a shot into the skin near the parts where there is sweating.

    Missed Dose

    • Call your doctor for an office visit.



    • Very bad side effects have happened when this drug has spread from where it is being used.
    • Please read the medication guide.


    • If you have an allergy to onabotulinumtoxinA, albumin, or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have an infection where the shot will be given.
    • If you have had a botulinum toxin product in the last 3 or 4 months.


    • If you have bleeding problems, talk with your doctor.
    • If you have lung disease, talk with your doctor.
    • If you have nerve disease, talk with your doctor.
    • If you have trouble swallowing, talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Tell your doctor if you are breast-feeding.
    • Tell your doctor if you are pregnant or plan on getting pregnant.

    Side Effects

    • Irritation where the shot is given.
    • Muscle weakness or changes in eyesight may happen. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
    • Neck pain.
    • Headache.
    • Less blinking.
    • Seeing double.
    • Dry eyes. Using artificial tears may help.
    • Eyelid droop.
    • Ulcers may rarely happen.
    • Bleeding in the eye may rarely happen.
    • Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Trouble breathing.
    • Trouble swallowing or speaking.
    • Very bad muscle pain or weakness.
    • Sudden change in eyesight, eye pain, or irritation.
    • Not able to control bladder.
    • Not able to pass urine.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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