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Sitagliptin and Simvastatin

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: JuvisyncT

    Uses
    • It is used to lower blood sugar in patients with high blood sugar (diabetes).
    • It is used to slow the progress of heart disease.
    • It is used to lower cholesterol and other harmful types of cholesterol in the body. Good cholesterol (HDL) levels rise.
    • It is used to lower triglycerides.
    • Sitagliptin raises insulin secretion from the pancreas and lowers sugar.
    • Simvastatin lowers cholesterol.

    Dosing

    How to take

    • Take as you have been told, even if you are feeling better.
    • Take in the evening.
    • Swallow whole. Do not chew, break, or crush.
    • Take with or without food. Take with food if it causes an upset stomach.
    • Follow the diet and workout plan that your doctor told you about.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.

    Safety



    Warnings

    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.
    • Please read the medication guide.

    Avoid

    • If you have an allergy to sitagliptin, simvastatin, or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have active liver disease or a rise in liver enzymes.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • If you abuse beer, wine, or mixed drinks, talk with your doctor.
    • If you have gallbladder disease, talk with your doctor.
    • If you have kidney disease, talk with your doctor.
    • If you have pancreatitis, talk with your doctor.
    • Check your blood sugar as you have been told by your doctor.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Have your blood work checked. Talk with your doctor.
    • Have an eye exam and visit the foot doctor every year.
    • Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.
    • Avoid grapefruit and grapefruit juice.
    • Avoid beer, wine, or mixed drinks.
    • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
    • Use birth control that you can trust to stop pregnancy while taking this drug.

    Side Effects

    • Headache.
    • Runny nose.
    • Sore throat.
    • Belly pain.
    • Hard stools (constipation). Drinking more liquids, working out, or adding fiber to your diet may help. Talk with your doctor about a stool softener or laxative.
    • Muscle pain or weakness.
    • Joint pain.
    • Low blood sugar. Signs include anger, shaking, a fast heartbeat, confusion, or sweating. Keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar.
    • Unsafe allergic effects may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5F (38C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Very low blood sugar or very high blood sugar.
    • Very upset stomach or throwing up.
    • Very bad belly pain.
    • Not able to eat.
    • Not able to pass urine.
    • Very bad muscle pain or weakness.
    • Flu-like signs.
    • Any bruising or bleeding.
    • Dark urine or yellow skin or eyes.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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