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Related terms
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    Related terms
    • Brand Names: U.S.: ProliaT;Xgevaź
    • Brand Names: Canada: Proliaź;Xgevaź

    • It is used to treat soft, brittle bones (osteoporosis).
    • It is used to stop bone loss.
    • It is used when treating some cancers.
    • Denosumab lowers bone loss and helps with bone mass and strength.
    • It lowers the chance of fractures or bone pain caused by cancer.


    How to take

    • It is given as a shot into the fatty part of the skin.
    • Your doctor will give this drug.
    • Take calcium and vitamin D as you were told by your doctor.



    • Please read the medication guide.


    • If you have an allergy to denosumab or any other part of this drug.
    • If you have a latex allergy, talk with your doctor.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have low calcium levels.
    • If you are pregnant or may be pregnant.
    • If you are a man with a sex partner who plans on getting pregnant at any time while you are being treated.
    • If you are breast-feeding.


    • If you have malabsorption syndrome or have had part of your bowel taken out, talk with your doctor.
    • If you have had thyroid or parathyroid surgery, talk with your doctor.
    • Very bad infections have been reported with use of this drug. If you have any infection, are taking antibiotics now or in the recent past, or have many infections, talk with your doctor.
    • Have your blood work checked. Talk with your doctor.
    • Have a bone density test. Talk with your doctor.
    • Have a dental exam before starting this drug.
    • Take good care of your teeth. See a dentist often.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Tell dentists, surgeons, and other doctors that you use this drug.
    • Use birth control that you can trust to stop pregnancy while taking this drug.

    Side Effects

    • Chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
    • Back pain.
    • Muscle pain.
    • Feeling tired or weak.
    • High cholesterol level.
    • Skin irritation.
    • Low calcium levels.
    • Low phosphate levels.
    • Headache.
    • Cough.
    • Upset stomach or throwing up.
    • Harm to the jaw bone may rarely happen.

    Contact a healthcare provider

    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Very bad jaw pain.
    • Very bad belly pain.
    • Any new or strange groin, hip, or thigh pain.
    • Numbness or tingling in your mouth.
    • Numbness or tingling in your hands or feet.
    • Very bad skin irritation.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

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    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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