• U.S. Brand Names: VimovoT
• Canadian Brand Names: VimovoT
• Pharmacologic Category: Nonsteroidal Anti-inflammatory Drug (NSAID), Oral;Proton Pump Inhibitor;Substituted Benzimidazole

• It is used to stop or treat NSAID-associated gastric ulcers in patients with a history of ulcers.
• It is used to treat arthritis.
• Esomeprazole helps avoid harm to the GI (gastrointestinal) tract caused by stomach acid or infection.
• Naproxen blocks chemicals that cause pain and swelling.

How to take

• To gain the most benefit, do not miss doses.
• Use as told, even if feeling better.
• Take 30 minutes before a meal.
• Take with a full glass of water.
• Swallow whole. Do not chew, break, or crush.

Missed Dose

• Take a missed dose as soon as you think about it.
• If it is close to time for the next dose, skip the missed dose and return to your normal time.
• Do not use two doses or extra doses.
• Do not change dose or stop drug. Talk with doctor.

Storage

• Store at room temperature.
• Protect from light.
• Protect from water. Do not store in a bathroom or kitchen.

Warnings

• This drug may raise the chance of heart attack, stroke, and high blood pressure. This has been observed with long-term use or at critical times (right after heart surgery). Use care if you have risk factors for heart disease (high blood pressure, high cholesterol, overweight, high blood sugar (diabetes), cigarette smoking, man older than 40 years of age, other family members with early heart disease, postmenopausal woman).
• Do not use this drug right before or after heart bypass surgery.
• This drug may raise the chance of ulcers or bleeding from the stomach or bowel. Talk with doctor.
• Unsafe reactions may happen. This drug cannot be taken while you are taking certain other drugs. Check all the drugs you are taking with your doctor.
• Please read the medication guide.

Avoid

• If you have an allergy to naproxen, esomeprazole, or any other part of this drug.
• Tell doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs involved.
• If you are more than 24 weeks pregnant.

Precautions

• If you are 65 or older, use this drug with care. You could have more side effects.
• If you have asthma, talk with doctor.
• If you have high blood pressure, talk with doctor.
• If you have kidney disease, talk with doctor.
• If you have liver disease, talk with doctor.
• If you have had an ulcer or bleeding from your stomach or bowel, talk with doctor.
• If you have a weak heart, talk with doctor.
• Use care if you have risk factors for soft, brittle bones called osteoporosis (alcohol use, cigarette smoking, other family members with brittle bones, taking drugs to treat seizures, taking steroids).
• Check all drugs you are taking with your doctor. This drug may not mix well with certain other drugs.
• Talk with doctor before using other aspirin, products that have aspirin, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain drugs, or vitamin E.
• Do not take colestipol or cholestyramine within 2 hours of this drug.
• Tell dentists, surgeons, and other doctors that you use this drug.
• You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
• Avoid alcohol (includes wine, beer, and liquor).
• Tell doctor if you are pregnant or plan on getting pregnant.
• Tell doctor if you are breast-feeding.

Side Effects

• Belly pain or heartburn.
• Loose stools.
• Headache.
• Upset stomach or throwing up. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Constipation. More liquids, regular exercise, or a fiber diet may help. Talk with doctor about a stool softener or laxative.
• Hip, spine, or wrist fractures may rarely happen.

Monitoring

• Change in health problem being treated. Is it better, worse, or about the same?
• Follow up with doctor.

Contact a healthcare provider

• If you suspect an overdose, call your local poison control center or ER right away.
• Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
• Chest pain or pressure.
• Fast heartbeat.
• Change in strength on one side greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
• Very upset stomach or throwing up.
• Very bad belly pain.
• Very bad loose stools.
• Major weight gain.
• Not able to eat.
• Dark urine or yellow skin or eyes.
• Feeling very tired or weak.
• Black, tarry, or bloody stools.
• Blood in the urine.
• Unusual bruising or bleeding.
• Very bad swelling or pain of hands or feet.
• Very bad bone pain.
• Very bad muscle pain or weakness.
• Seizures.
• Any rash.
• Health problem is not better or you are feeling worse.

General Statements

• If you have a very bad allergy, wear allergy ID at all times.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep all drugs out of the reach of children and pets.
• Most drugs can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• In Canada return any unused drugs back to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th for more facts about the right way to get rid of unused drugs.
• Keep a list of all your drugs (prescription, natural products, supplements, vitamins, OTC) with you. Give this list to your doctor.
• Call your doctor for health help about side effects. You may also call the FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.
• Talk with doctor before starting any new drug, including OTC, natural products, or vitamins.

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