Table of Contents > Drug > Collagenase (Systemic) Print

Collagenase (Systemic)

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Xiaflex®

    Uses
    • It is used to treat cords formed in patients with Dupuytren's contracture.
    • Collagenase helps break the cord causing the bent finger.

    Dosing

    How to take

    • Your doctor will give this drug.
    • Do not bend or straighten the fingers of your treated hand until your doctor tells you it is okay.
    • Do not try to straighten your treated finger.
    • Keep your treated hand raised until bedtime on the first day.
    • You will need to go back to your doctor's office the next day.
    • You will be given a splint to wear on the treated finger at bedtime for up to 4 months.
    • Do your finger exercises each day.
    • Do not start normal actions with the treated hand until doctor tells you it is okay.

    Storage

    • This drug will be given to you in a hospital or doctor's office. You will not store it at home.

    Safety



    Warnings

    • Please read the medication guide.

    Avoid

    • If you have an allergy to collagenase or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

    Precautions

    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • If you have bleeding problems, talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Irritation or swelling where the shot was given.
    • Bleeding.
    • Bruising.

    Monitoring

    • Change in the health problem being treated. Is it better, worse, or about the same?
    • Follow up with the doctor.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Unable to bend treated finger after swelling goes down.
    • Very bad numbness and tingling.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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