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Methoxsalen (Systemic)


Related terms
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    Related terms
    • Brand Names: U.S.: 8-MOP®;Oxsoralen-Ultra®;Uvadex®
    • Brand Names: Canada: Oxsoralen-Ultra®;Oxsoralen® Capsule;UltramopT

    • It is used to treat white patches on your skin (vitiligo).
    • It is used to treat psoriasis.
    • It is used to treat skin cancer.
    • Methoxsalen raises skin color.
    • It raises the sensitivity of the skin to light therapy.
    • It harms cancer cells causing their death.
    • It lowers irritation.


    How to take

    • Take 2 hours before being exposed to UV light.
    • Take this drug with food.
    • Avoid eating foods such as carrots, celery, cloves, figs, lemons, limes, mustard, or parsley.

    Missed Dose

    • Call your doctor to find out what to do.


    • Store at room temperature.
    • Protect capsules and gelcaps from water. Do not store in a bathroom or kitchen.



    • Very bad burns may happen if this drug is not used the right way. Follow what your doctor told you to do closely.
    • There is more than 1 brand of this drug. One brand cannot safely be used for the other. Your doctor will tell you about any needed change.


    • If you have an allergy to methoxsalen or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Melanoma or squamous cell cancer.
    • If you sunburn easily.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.


    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Wear sunglasses during and for 24 hours after care. Protect lips with lipstick that has sunscreen.
    • Do not go over the time you are told to use.
    • Sun or UV rays may age the skin and raise the chance of skin cancer.
    • You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
    • Use birth control that you can trust to stop pregnancy while taking this drug.

    Side Effects

    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Sunburn.
    • Skin irritation.
    • Itching.


    • Change in the health problem being treated. Is it better, worse, or about the same?
    • Follow up with the doctor.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Very bad skin irritation.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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