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Estrogens (Conjugated/Equine, Topical)

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Premarin®
    • Brand Names: Canada: Premarin®

    Uses
    • It is used to stop or lower the signs of stopping periods (menopause).
    • It is used to treat vaginal irritation and dryness.
    • Estrogens are used to add estrogen to the body.

    Dosing

    How to take

    • Take this drug at the same time of day.
    • There may be days when you will not take this drug.
    • Use cream vaginally.

    Missed Dose

    • Put on a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not put on 2 doses or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.

    Safety



    Warnings

    • Estrogens, when used in women after stopping periods (menopause), may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to your doctor.
    • Do not take estrogens if you are pregnant. If you get pregnant while taking this drug, call your doctor right away.
    • Do not take estrogens to stop heart disease or dementia. Using estrogens may raise your chances of having a heart attack, a stroke, breast cancer, or a blood clot.
    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.

    Avoid

    • If you have an allergy to estrogens (conjugated/equine) or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Bleeding disorder, blood clots, breast cancer (except in some cases where the cancer has spread), liver disease, recent heart attack, recent stroke, tumor where estrogen makes it grow, or vaginal bleeding.
    • If you have surgery and need bed rest.
    • If you are pregnant or may be pregnant.

    Precautions

    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • There may be a higher chance of endometrial or breast cancer.
    • If you have asthma, talk with your doctor.
    • If you have any blood flow problems, talk with your doctor.
    • If you have high blood sugar (diabetes), talk with your doctor.
    • If you have gallbladder disease, talk with your doctor.
    • If you have heart disease, talk with your doctor.
    • If you have high calcium levels, talk with your doctor.
    • If you have had high triglyceride levels, talk with your doctor.
    • If you have kidney disease, talk with your doctor.
    • If you have migraine headaches, talk with your doctor.
    • If you have porphyria, talk with your doctor.
    • If you have seizures, talk with your doctor.
    • Have your blood pressure and heart rate checked often. Talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • If you are taking a blood thinner, have your blood work checked. Talk with your doctor.
    • Have a bone density test. Talk with your doctor.
    • Do monthly breast self-exams and have a gynecologic exam every year.
    • Have an eye exam every year.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Do not take St John's wort, dong quai, black cohosh, saw palmetto, red clover, or ginseng with this drug.
    • Limit your drinking of wine, beer, or mixed drinks.
    • Avoid cigarette smoking. People older than 35 years of age and/or smoking more than 15 cigarettes per day have more chance for heart disease.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Headache.
    • Belly pain.
    • Breast pain.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Enlarged breasts.
    • Change in sex ability. This most often goes back to normal.
    • Gallbladder disease, blood clots, heart attacks, and other blood vessel problems may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Chest pain or pressure.
    • Trouble breathing.
    • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
    • Swelling, warmth, or pain in the leg or arm.
    • Very bad headache.
    • Very upset stomach or throwing up.
    • Not able to eat.
    • Any bruising or bleeding.
    • Dark urine or yellow skin or eyes.
    • Change in how contact lenses feel in the eyes.
    • A lump in the breast or breast soreness.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.
    • Read the package insert for more details.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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