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Estradiol (Topical)


Related terms
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    Related terms
    • Brand Names: U.S.: Estrace®;Estring®;Vagifem®
    • Brand Names: Canada: Estrace®;Estring®;Vagifem®;Vagifem® 10

    • It is used to treat vaginal irritation and dryness caused by change of life.
    • Estradiol helps bladder and vagina tone.


    How to take

    • Vaginal cream/tablet:
    • Use cream or tablet vaginally.
    • Wash your hands and applicator after use.
    • Vaginal ring:
    • Put into the vagina and leave in place for 90 days.
    • Follow how to use as you have been told by your doctor or read the package insert.
    • Take out ring at the start of the 13th week.
    • Put in a new ring.
    • To use, wash your hands and take ring from the pouch.
    • Press sides of ring at the same time between thumb and index finger and put folded ring into the vagina.
    • Perfect placement is not needed for the ring to work. The ring will not hurt.
    • To take off, hook your index finger around the rim or hold rim between index finger and middle finger and pull out.
    • Do not throw the vaginal ring in the toilet.

    Missed Dose

    • Use a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not use 2 doses or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.


    • Store at room temperature.



    • Estrogens, when used in women after stopping periods (menopause), may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to your doctor.
    • Do not take estrogens to stop heart disease or dementia. Using estrogens may raise your chances of having a heart attack, a stroke, breast cancer, or a blood clot.
    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.
    • Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.


    • If you have an allergy to estradiol or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Blood clots, breast cancer, liver disease, recent heart attack, recent stroke, tumor where estrogen makes it grow, or vaginal bleeding.


    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • There may be a higher chance of endometrial or breast cancer.
    • If you have any blood flow problems, talk with your doctor.
    • If you have heart disease, talk with your doctor.
    • Do monthly breast self-exams and have a gynecologic exam every year.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Avoid cigarette smoking. People older than 35 years of age and/or smoking more than 15 cigarettes per day have more chance for heart disease.
    • Limit your drinking of wine, beer, or mixed drinks.

    Side Effects

    • Vaginal irritation.
    • For women, vaginal yeast infection. Report itching or discharge.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Swelling, warmth, or pain in the leg or arm.
    • Very bad vaginal irritation.
    • A lump in the breast or breast soreness.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.
    • Read the package insert for more details.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (

    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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