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Nilotinib

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Tasignaź
    • Brand Names: Canada: Tasignaź

    Uses
    • It is used to treat leukemia.
    • It is used to treat stomach cancer.
    • Nilotinib harms leukemia cells and stops their growth.
    • It harms cancer cells causing their death.

    Dosing

    How to take

    • Use as you have been told, even if you are feeling better.
    • Take on an empty stomach. Take 1 hour before or 2 hours after meals.
    • Take with a full glass of water.
    • Swallow whole. Do not chew, break, or crush.
    • Capsule may be opened and contents sprinkled on 1 teaspoon of applesauce. Swallow right away.

    Missed Dose

    • Skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.
    • Do not change the dose or stop this drug. Talk with the doctor.

    Storage

    • Store at room temperature.
    • Protect from water. Do not store in a bathroom or kitchen.

    Safety



    Warnings

    • An unsafe fast heartbeat may happen. Tell your doctor if you have a history of fast heartbeats, low potassium or magnesium levels. Your heartbeat will be watched with an ECG.
    • Take this drug on an empty stomach. Take 1 hour before or 2 hours after meals.
    • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.
    • Please read the medication guide.

    Avoid

    • If you have an allergy to nilotinib or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have any of these health problems: Long QT syndrome, low magnesium levels, or low potassium levels.
    • If you are allergic to lactose, talk with the doctor.
    • If you are pregnant or may be pregnant.
    • If you are breast-feeding.

    Precautions

    • If you have a fast heartbeat, talk with your doctor.
    • If you have heart disease, talk with your doctor.
    • Your doctor will watch your heartbeat with a test called an ECG.
    • If you have liver disease, talk with your doctor.
    • If you have had an irritated pancreas, talk with your doctor.
    • If you have had recent stomach surgery or any stomach problems, talk with your doctor.
    • Have your blood work checked. Talk with your doctor.
    • If you have thyroid disease, talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Talk with your doctor before getting any vaccines. Use with this drug may either raise the chance of an infection or make the vaccine not work as well.
    • Do not take St John's wort with this drug. This drug may not work as well.
    • Avoid grapefruit and grapefruit juice.
    • Talk with your doctor before using products that have aspirin, blood thinners, garlic, ginseng, ginkgo, ibuprofen or like products, pain drugs, or vitamin E.
    • Use birth control that you can trust to stop pregnancy while taking this drug.

    Side Effects

    • Anemia, low white blood cell count, and low platelet count. This drug may need to be stopped.
    • Chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
    • Headache.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Not hungry.
    • Hard stools (constipation).
    • Loose stools (diarrhea).
    • Swelling in the arms or legs.
    • High blood pressure.
    • High blood sugar.
    • Muscle pain.
    • Hair loss.
    • Not able to sleep.
    • Cough.
    • Runny nose.
    • Feeling tired or weak.
    • Skin irritation.
    • Harm to the liver may rarely happen.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
    • Chest pain or pressure, a fast heartbeat, or passing out.
    • Trouble breathing.
    • Very upset stomach or throwing up.
    • Very loose stools (diarrhea).
    • Very bad belly pain.
    • Very bad headache.
    • A big weight gain.
    • Very bad swelling or pain of hands or feet.
    • Any bruising or bleeding.
    • Dark urine or yellow skin or eyes.
    • Feeling very tired or weak.
    • Sudden change or loss of eyesight.
    • Any rash.
    • Side effect or health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2013 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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