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Phosphatidylserine

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Also listed as: Phosphatidyl serine
Related terms
Background
Evidencetable
Tradition
Dosing
Safety
Interactions
Attribution
Bibliography

Related Terms
  • BC-PS, bovine cortex, cephalin, egg phosphatidylserine, egg-PS, E-PS, kephalin, phos serine, PS, soybean phosphatidylserine, soybean-PS, S-PS.

Background
  • Phosphatidylserine is present in cell membranes and is the major molecule of its kind in the brain. Phosphatidylserine is essential for cell-to-cell communication and other cell functions.
  • Phosphatidylserine is present in greater amounts in animal-based foods, such as liver and kidneys, than in plants. Plant sources include soy beans, white beans, cabbage, carrots, whole-grain barley, and rice.
  • Phosphatidylserine is most commonly used for the treatment of central nervous system (CNS) disorders. It is commonly used to treat mental disorders ranging from age-associated memory impairment (AAMI) to Alzheimer's disease. Current evidence suggests that phosphatidylserine may benefit those with AAMI to a greater degree than it does those with Alzheimer's disease. However, more research is needed.
  • Ingestion of phosphatidylserine from bovine brain cortex (BC-PS) carries a risk of transmission of infectious disease, such as bovine spongiform encephalopathy (commonly known as mad cow disease). However, phosphatidylserine derived from soybeans (S-PS) does not carry that risk, and it appears to be equally effective as BC-PS.
  • Soy-derived phosphatidylserine (S-PS) is listed on the U.S. Food and Drug Administration (FDA) Generally Recognized as Safe (GRAS) list.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Limited evidence suggests that phosphatidylserine (PS) may have a role in treating age-related memory disorders, including Alzheimer's disease. Further research is needed.

C


Limited evidence has indicated that PS supplementation may have an effect on different types of stress. Further research is required before conclusions may be drawn.

C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)


Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

  • Alzheimer's disease, anti-inflammatory, blood clotting disorders, dementia, memory.

Dosing

Adults (18 years and older)

  • Although phosphatidylserine derived from bovine cortex (BC-PS) has been used in studies, it is currently not administered to humans because of possible transfer of infectious diseases, including bovine spongiform encephalopathy (commonly known as mad cow disease). Soybean phosphatidylserine (PS) is currently used instead of BC-PS.
  • For age-related memory disorders, 100 milligrams of BC-PS has been taken by mouth three times daily for three months, and 200 milligrams of phosphatidylserine has been taken by mouth twice daily for six months.
  • For stress, 200 milligrams of soy-based phosphatidylserine has been taken by mouth daily for 42 days, and also, 600 milligrams of soy-derived phosphatidylserine has been taken by mouth daily for 10 days.

Children (under 18 years old)

  • There is no proven safe or effective dose for phosphatidylserine in children.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Allergies

  • Avoid with known allergy or hypersensitivity to phosphatidylserine.

Side Effects and Warnings

  • Soybean phosphatidylserine (PS) is likely safe when used in dosages up to 600 milligrams daily for up to 10 days.
  • Phosphatidylserine may cause nausea, stomach discomfort, or insomnia.
  • Phosphatidylserine may increase blood clotting. Caution is advised in patients with blood clotting disorders or those taking drugs, herbs, or supplements that may increase the risk of bleeding. Dosing adjustments may be necessary.
  • Use cautiously in patients with sickle cell anemia, as some patients with this disease are more likely to develop blood clots. Theoretically, phosphatidylserine may increase the risk of blood clotting.
  • Use cautiously in patients with antiphospholipid syndrome (an autoimmune disorder that causes blood clots and problems during pregnancy), as, in these patients, antiphospholipid antibodies may bind phosphatidylserine present in cells.
  • Avoid phosphatidylserine if derived from bovine cortex (BC-PS), because of possible transfer of infectious diseases, including bovine spongiform encephalopathy (commonly known as mad cow disease). Currently, BC-PS is not used in clinical trials.
  • Avoid medicinal use in pregnant or breastfeeding women or in children, due to a lack of evidence and safety data.
  • Avoid in patients with known allergy or hypersensitivity to phosphatidylserine.

Pregnancy and Breastfeeding

  • Phosphatidylserine (PS) is likely safe as found in breast milk; approximately 75 milligrams of phospholipids are normally present in every 100 milliliters of human milk, including phosphatidylserine, ethanolamine, phosphatidylcholine, phosphatidylinositol, and sphingomyelin.
  • In nonallergic women, PS is likely safe when consumed in amounts generally found in foods.
  • Avoid medicinal use in pregnant or breastfeeding individuals or in children, due to a lack of evidence and safety data.

Interactions

Interactions with Drugs

  • PS may increase the risk of blood clot formation, which may alter the effectiveness of drugs that affect bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin (Coumadin®) or heparin, antiplatelet drugs such as clopidogrel (Plavix®), and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
  • Phosphatidylserine may also interact with agents that affect the immune system, anti-inflammatory agents, athletic performance-enhancing agents, and neurologic agents.

Interactions with Herbs and Dietary Supplements

  • Phosphatidylserine may increase the risk of blood clot formation, and it may interact with herbs and supplements that are believed to affect bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
  • Phosphatidylserine may also interact with anti-inflammatory herbs and supplements, athletic performance-enhancing herbs and supplements, herbs and supplements that affect the immune system, and neurologic herbs and supplements.

Attribution
  • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography
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  2. Beaumont C, Canonne-Hergaux F. [Erythrophagocytosis and recycling of heme iron in normal and pathological conditions; regulation by hepcidin]. Transfus Clin Biol 2005;12(2):123-130.
  3. Bessos H, Seghatchian J. Red cell storage lesion: the potential impact of storage-induced CD47 decline on immunomodulation and the survival of leucofiltered red cells. Transfus Apher Sci. 2005;32(2):227-232.
  4. Ceccatelli S, Tamm C, Sleeper E, et al. Neural stem cells and cell death. Toxicol Lett 2004;149(1-3):59-66.
  5. Crook T, Petrie W, Wells C, et al. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28(1):61-66.
  6. Emmelot P, Van Hoeven RP. Phospholipid unsaturation and plasma membrane organization. Chem Phys Lipids 1975;14(3):236-246.
  7. Folch J. The chemical structure of phospatidyl serine. J Biol Chem 1948;174(2):439-450.
  8. Haberkorn U, Altmann A, Mier W, et al. Molecular imaging of tumor metabolism and apoptosis. Ernst Schering Found Symp Proc 2007;(4):125-152.
  9. Hallgren O, Aits S, Brest P, et al. Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells). Adv Exp Med Biol 2008;606:217-240.
  10. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  11. Maggioni, M., Picotti, G. B., Bondiolotti, G. P., et al. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr.Scand. 1990;81(3):265-270.
  12. Mountz JD, Hsu HC, Wu Q, et al. Molecular imaging: new applications for biochemistry. J Cell Biochem Suppl 2002;39:162-171.
  13. Nerozzi, D., Aceti, F., Melia, E., et al. [Phosphatidylserine and memory disorders in the aged]. Clin.Ter. 3-15-1987;120(5):399-404.
  14. Ransmayr, G., Plorer, S., Gerstenbrand, F., et al. Double-blind placebocontrolled trial of phosphatidylserine in elderly patients with arteriosclerotic encephalopathy. Clin Trials J 1987;24:62-72.
  15. Rosadini, G., Sannita, W. G., Nobili, F., et al. Phosphatidylserine: quantitative EEG effects in healthy volunteers. Neuropsychobiology 1990;24(1):42-48.

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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