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Lecithin/Drug Interactions:- Anticoagulants and antiplateletsAnticoagulants and antiplatelets: In humans, lecithin has been shown to increase platelet adhesion (8).
- Antilipemic agentsAntilipemic agents: Based on several clinical studies, lecithin may improve the lipid profile by reducing LDL cholesterol and the LDL cholesterol:HDL cholesterol ratio and increasing HDL cholesterol (21; 23; 24; 22; 33). Theoretically, concurrent use of lecithin and antilipemic agents may cause added cholesterol-lowering effects.
- Cholinesterase inhibitorsCholinesterase inhibitors: The effect of lecithin with cholinesterase inhibitors remains equivocal. The combination of physostigmine and lecithin enhanced cognitive functions in Alzheimer's patients (34; 15). However, several studies did not find an effect of physostigmine, whether or not administered with lecithin (31; 35; 36). In a few clinical studies, lecithin had an added beneficial effect in Alzheimer's patients when used with tacrine (13; 37); however, the majority of studies have found no effect with tacrine and lecithin (14; 38; 39; 40; 41; 42; 43; 44).
- DiclofenacDiclofenac: Lecithin has been studied in combination with topical diclofenac for local treatment of sprains and strains; lecithin appears to facilitate absorption of diclofenac (45; 46; 47).
- Ergot derivativesErgot derivatives: The combination of lecithin and ergoloid mesylates had no effect on cognitive function in Alzheimer's patients (48).
- Heavy metal antagonists/chelating agentsHeavy metal antagonists/chelating agents: No interactions between the trivalent chelating agent desferrioxamine and lecithin were reported in a clinical trial on patients with Alzheimer's disease (49).
- LithiumLithium: The addition of lecithin as comedication to lithium had no effect on tardive dyskinesia (29).
- Nootropic agentsNootropic agents: The effects of lecithin with nootropic agents (or memory enhancers) remain unclear. Lecithin coadministered with piracetam had a beneficial effect in patients with Alzheimer's disease in one study (16) and no effect in another (30).
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Lecithin/Herb/Supplement Interactions:- Acetyl-L-carnitineAcetyl-L-carnitine: As lecithin, carnitine, and glucose all influence acetylcholine metabolism, the possibility of synergistic interactions was investigated with a battery of cognitive tests. Reaction times were more rapid when carnitine and a glucose drink were taken together. Neither mood nor the ability to sustain attention were influenced by these procedures (50).
- Anticoagulants and antiplateletsAnticoagulants and antiplatelets: In humans, lecithin has been shown to increase platelet adhesion (8).
- AntilipemicsAntilipemics: Based on several clinical studies, lecithin may improve the lipid profile by reducing LDL cholesterol and the LDL cholesterol:HDL cholesterol ratio and increasing HDL cholesterol (21; 23; 24; 22; 33). Theoretically, concurrent use of lecithin and antilipemic agents may cause added cholesterol-lowering effects.
- CholineCholine: Choline is a component of lecithin. Human and animal studies show that lecithin increased plasma free choline levels (17; 51; 52; 30; 53; 11; 54).
- Nootropic agentsNootropic agents: The effects of lecithin with nootropic agents (or memory enhancers) remain unclear. Lecithin coadministered with piracetam had a beneficial effect in patients with Alzheimer's disease in one study (16) and no effect in another (30).
- PhosphatidylserinePhosphatidylserine: A complex of lecithin and phosphatidylserine resulted in significant changes in pituitary adrenal activity (27).
- SitostanolSitostanol: In human study, sitostanol reduced cholesterol absorption but only if formulated with lecithin (24). The solubility of sitostanol in artificial bile was greatly increased by including lecithin (24).
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Lecithin/Food Interactions:- Insufficient available evidence.
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Lecithin/Lab Interactions:- ACTH levelsACTH levels: Treatment with 400mg of PAS resulted in a pronounced blunting of both serum ACTH and cortisol (27).
- Choline levelsCholine levels: Lecithin increased plasma free choline levels (17; 51; 52; 30; 53; 11; 54).
- Coagulation panelCoagulation panel: In humans, lecithin has been shown to increase platelet adhesion (8).
- Cortisol levelsCortisol levels: Treatment with 400mg of PAS resulted in a pronounced blunting of both serum ACTH and cortisol (27).
- EEGEEG: Lecithin had no effect on EEG activity (10; 42; 36).
- HemoglobinHemoglobin: According to a randomized controlled trial, hemoglobin levels tended to decrease, and the decrease was significant but clinically irrelevant (55).
- Lecithin/sphingomyelin ratioLecithin/sphingomyelin ratio: Lecithin as artificial surfactant may have an effect on the lecithin/sphingomyelin ration in preterm babies (56).
- Lipid profileLipid profile: Based on several clinical studies, lecithin may improve the lipid profile by reducing LDL cholesterol and the LDL cholesterol:HDL cholesterol ratio and increasing HDL cholesterol (21; 23; 24; 22; 33).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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